IMPORTANT SAFETY INFORMATION
Do not take AZILECT® (rasagiline tablets) if you are taking meperidine as it could result in a serious reaction such as coma or death. Also, do not take AZILECT with tramadol, methadone, propoxyphene, dextromethorphan, St. John’s wort, or cyclobenzaprine. You also should not take AZILECT with other monoamine oxidase inhibitors (MAOIs), as it could result in an unsafe rise in blood pressure. Read More Important Safety Information

About Parkinson's Disease

What is Parkinson's disease?

Parkinson's disease is a chronic, progressive disorder in which dopamine levels in your brain decline over time. Dopamine is the chemical messenger in your brain partly responsible for controlling movement and coordination in your body. It is used to send messages to your muscles to make them move properly.

In Parkinson's disease, the nerve cells that produce dopamine are damaged and unable to produce enough dopamine for normal movement. This decline of dopamine causes a variety of symptoms and problems with movement.

Parkinson's disease is progressive, which means symptoms may get worse as time goes by.

Who gets Parkinson's disease?

Approximately 1 million people in the United States have Parkinson's disease. Most people with Parkinson's are diagnosed when they are in their 60s, but estimates suggest that up to 15% of people with Parkinson's may have an early onset form of the disease, meaning they are diagnosed before the age of 40.

The chances of developing PD increase with age, and the disease affects slightly more men than women.

What causes Parkinson's?

Although great progress has been made in understanding the disease, its cause is still unknown. It is thought that a combination of environmental and genetic factors contribute to the development of Parkinson's.

Progress is being made

There are many effective therapies for Parkinson's disease today, and new medications and approaches are continually under development.

Many people find that, with the help of therapy, they can continue to work and enjoy the activities they love for many years after diagnosis.

INDICATION
AZILECT® (rasagiline tablets) is indicated for the treatment of Parkinson’s disease (PD).

IMPORTANT SAFETY INFORMATION
  • Do not take AZILECT if you are taking meperidine as it could result in a serious reaction such as coma or death. Also, do not take AZILECT with tramadol, methadone, propoxyphene, dextromethorphan, St. John’s wort, or cyclobenzaprine. You also should not take AZILECT with other monoamine oxidase inhibitors (MAOIs), as it could result in an unsafe rise in blood pressure
  • Increases in blood pressure may occur during treatment with AZILECT. Inform your physician if you have a history of high blood pressure. Possible symptoms of an unsafe rise in blood pressure include severe headache, blurred vision, difficulty thinking, seizure, chest pain, and nausea/vomiting. It is important that if you experience these symptoms that you speak with your doctor or seek medical attention. When AZILECT is taken at recommended doses, restriction of foods and beverages containing a substance called tyramine is ordinarily not required. However, it is recommended that you avoid foods containing high amounts of tyramine such as aged cheeses as some patients may have an increased sensitivity that could lead to an unsafe rise in blood pressure as described above
  • Inform your physician if you are taking, or planning to take, any prescription or over-the-counter drugs, especially antidepressants and ciprofloxacin. The combination of MAO-B inhibitors such as AZILECT and antidepressants has resulted in a serious and sometimes fatal condition called serotonin syndrome
  • If you experience episodes of falling asleep or drowsiness during activities of daily living, do not drive and exercise caution until you contact your physician
  • If you have moderate to severe liver disease, you should not take AZILECT. You should not exceed a dose of 0.5 mg per day of AZILECT if you have mild liver disease or are taking ciprofloxacin. Patients should not exceed a dose of 1 mg per day of AZILECT because of the risk of increased blood pressure
  • All PD patients should be monitored for a change in blood pressure, uncontrolled movements (dyskinesia), hallucinations, impulse control, confusion, and melanoma (skin cancer). A possible rise in body temperature may occur upon stopping AZILECT
  • The most common side effects seen with AZILECT alone are flu syndrome, joint pain, depression, and indigestion; when taken with a dopamine agonist are swelling of the legs, fall, joint pain, cough, and inability to sleep; and when taken with levodopa are uncontrolled movements (dyskinesia), accidental injury, weight loss, low blood pressure when standing, vomiting, anorexia, joint pain, abdominal pain, nausea, constipation, dry mouth, rash, abnormal dreams, fall, and swelling of tendons
  • You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
  • Please see full Prescribing Information.